Is there a way to change the "highlighted file" color on Windows 7?

In the Windows 7 file explorer, when you select a file, the entire line highlights in a light blue color.

Is there a way to change this color, presumably via a registry tweak?

Answer

Edit:

If you mean the hot-track effect it's probbly not possible to "manually" tweak it.

I just found this to clarify it:

In regard to Windows 7, I came across this interesting piece of information: When hovering over the icons in the taskbar, the color highlight of the “glass” button is actually different from application to application. How it works is dynamically abstracting the color values of the application icon to find the most dominant RGB value. Besides the obvious eye-candy, this feature delivers some sentimental value by making it easy to identify applications by color.

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The only thing you can do is try to change your Theme settings.

Its under Personalization, Window Color and Appearance, Advanced Appearance options under "Selected items"

Two options you should try:

Standard Windows color settings:

Or the Aero theme colors: